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Year : 1978  |  Volume : 10  |  Issue : 3  |  Page : 251-254

Modification of guanethidine pressor response by some sympathomimetic amines in anaesthetized dog



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P S Zade


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. Modification by some sympathomimetic amines of the pressor response produced by i.v. guanethidine was studied in dog. Guanethidine was administered as a bolus i.v. injection in a dose of 3 mg/kg. The sympathomimetic amines used were mephentermine, amphetamine, tyramine, ephedrine, phenylephrine and methoxamine. These produced blockade of guanethidine pressor response to varying degrees. Mephentermine was found to be the most potent, while methoxamine the least potent in this respect. Structure activity relationship of sympathomimetic amines in relation to their ability to block guanethidine pressor response is discussed.






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