IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 227 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1141    
    Printed56    
    Emailed0    
    PDF Downloaded100    
    Comments [Add]    

Recommend this journal

 

 SHORT COMMUNICATION
Year : 1978  |  Volume : 10  |  Issue : 2  |  Page : 163-166

Antifilarial activity of mebendazole against Setaria cervi



Correspondence Address:
K C Singhal


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

. Mebendazole administered orally upto a dose of 500 mg/kg was ineffective either in eradicating microfilariae from the peripheral circulation of rats infected with Setaria cervi or in affecting the implanted adult worms. The lack of effect of mebendazole is likely due to its low absorption from the alimentary tract. Mebendazole was also ineffective in reducing the survival time of microfilariae in vitro. Mebendazole in low doses produced stimulation of the movements of adult worm and nerve-muscle complex which was not blocked by prior addition of d-tubocurarine. This suggests that acetyl-choline is not involved in bringing about the stimulant effect. At higher concentrations, the drug caused complete irreversible paralysis of the whole worm as well as the nerve-muscle complex of S. cervi. The dose required to produce an equivalent effect in the nerve-muscle complex was 1/10th of that required for the whole worm suggesting the existence of a cuticular barrier.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow