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 RESEARCH PAPER
Year : 1978  |  Volume : 10  |  Issue : 2  |  Page : 127-133

Studies on the sympathomimetic effects of debrisoquine on smooth muscle of rat



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M P Patel


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. The adrenergic neurone blocking and sympathomimetic effects of debrisoquin (DBQ) were studied on anococcygeus and vas deferens preparation of rat to find out correlation between the two effects and the mechanism of action of the latter. DBQ (5.71 x IO-9 M) caused a reversible neurone blocking effect as well as potentiated responses to noradrenaline (NA) on anococcygeus muscle. Higher concentrations of DBQ(1.17 x10-6 M) caused similar effects on vas deferens. Reserpinization abolished contractile responses due to DBQ a s well as its potent- iating effect of NA responses in anococcygeus muscle, while it failed to modify the potentiation of NA responses by DBQ in vas deferens. Phentolamine (1 x 10-7 M) completely antagonised the contractions due to DBQ on anococcygeus muscle of rat. Nialamide (3.35 x 10-5 M) completely antagonised the potentiating effect of DBQ on NA responses in anococcygeus muscle, while antagonism of pontentiating effect of DBQ by nialamide in vas deferens was partial but significant. There is a significant correlation between the neuronal blocking and sympathomimetic effects of DBQ. The mechanism of the sympathomimetic effect of DBQ is probably different in the two preparations.






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