| SHORT COMMUNICATION
|Year : 1977 | Volume
| Issue : 3 | Page : 221-224
Antiinflammatory, immunosuppressive and some related pharmacological actions of the water extract of Neem Giloe (Tinospora cordifolia): A preliminary report
VK Pendse, AP Dadhich, PN Mathur, MS Bal, BR Madan
The water extract of the stem of Neem Giloe (Tinospora cordifolia), an Indian Indigenous plant, was screened for anti-inflammatory, analgesic and antipyretic actions in albino rats and immunosuppressive effect in albino rabbits. lt significantly inhibited acute inflammatory response evoked by carrageenin in a doss of 50 mg/100 g given orally and intraperitoneally. In chronic inflammation produced by croton-oil in granuloma pouch technique, 20 mg/100 g of the water extract significantly inhibited granulation tissue response; the reduction in exudative response and increase in t he weight of adrenal glands were not significant. A significant inhibition of primary and secondary phases was observed In adjuvant-induced arthritis. It significantly inhibited antibody formation by typhold "H" antigen. A mild analgesic effect of its own as well as potentiation of morphine analgesia were possessed by the extract but it was devoid of antipyretic effect.
V K Pendse
Source of Support: None, Conflict of Interest: None