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 RESEARCH PAPER
Year : 1977  |  Volume : 9  |  Issue : 2  |  Page : 147-150

Blood level and urinary excretion of diethylcarbamazine citrate in bull-calves


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L D Sharma


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The concentration of diethylcarbamazine citrate in the blood of bull-calves reached the peak level (1.46 ( 0.24 mg/100 ml) within 10 min after an intramuscular dose of 50 mg/kg. The blood levels gradually receded to 0.94 ( 0.20, 0.24 ( 0.06, 0.31 ( O.17. 0.28 ( O.18 and 0.26 ( 0.12 mg/100 ml at 1, 3, 6, 9, and 12 hr post-injection and completely disappeared from circulation at 22 hr. The urinary excretion of diethycarbamazine started within 3 hr of injection. The excretion rate was 0.85 ( 0.12, 1.5 ( 0.18, 1.2 ( 0.17, 0.48(0.14, 0.29 ( 0.24 and 0.27 ( 0.23 mg/ml during 3.9, 16.22. 33 and 48 hr respectively. From about 6 day onwards the urinary excretion tapered out to zero in course of 63-70 days.






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