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 RESEARCH PAPER
Year : 1976  |  Volume : 8  |  Issue : 4  |  Page : 201-204

Effect of centrally administered glucagon on total blood cholesterol level in dogs



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K N Singh


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"Glucago" administration by intracerebroventricular (I. C. V.) route resulted in lowering of total blood cholesterol level by 29.89% with a maximum decrease within 15 minutes. The hypocholesterolaemic effect of glucagon was not obtained in vasgotomized dogs, leading to the hypothesis that I. C. V. glucagon stimulates the vagal centre. In hepatectomized dogs. in which both vegi were intact, intraventricular administration of glucagon did of cause any hypocholesterolaemic effect and this suggests that centrally administered glucagon exerts its effect on liver through vagus. It is possible that I. C. V. administered glucagon stimulates the vagal centre which brings about a decrease in total blood cholesterol level by inhibiting the synthesis or its release from the liver.






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