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 RESEARCH PAPER
Year : 1976  |  Volume : 8  |  Issue : 3  |  Page : 161-166

Possible pharmacokinetic explanation for the rate dependent toxicity of furosemide


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N A Kshirsagar


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This study was carried out in order to find out a possible pharmacokinetic explanation for the rate dependent toxicity of turosemide. Twelve cats and eight patients of chronic renal failure were given turosemide intravenously at different rates and doses. Plasma turosemide levels were fluorimetrically estimated in serial blood samples. The elimination curves obtained were studied to get an idea about the compartmental distribution of turosemide when given at different rates and doses. The results provide a possible explanation for the rate dependent ototoxic effect of high doses of turosemide. This study may also provide useful guidelines in deciding the rate of infusion when high doses of furosemide are to be given to patients.






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