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 RESEARCH PAPER
Year : 1972  |  Volume : 4  |  Issue : 3  |  Page : 174-177

Anticonvulsant activity of dimethindene maleate (Foristal – Ciba)


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Correspondence Address:
Chandra Vimal


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A number of antihistaminics have occasionally been tried in the treatment of epilepsy and related disorders (Douglas, 1965). Vimal chandra, Bapat and Dhawan (1969) hare reported the effectiveness of a large number of antihistaminics against Supra-maximal Electroshock Serzure Pattern test (SMES test). In our previous study we had also indicated that the anticonvulsant activity is unrelated to antihistaminic activity of this class of compounds (Vimal Chandra, Bapat and Dhawan, 1969; 1970). In the present study the anticonvulsant action of dimethindene against SMES test, Metrazole seizure threshold test (MST) and 5-HT induced convulsions was determined and compared with that of diphenylhydantoin, diphenhydramine and cyproheptadine. A preliminary report of the part of this work has already been published (Vimal Chandra. Bapat. Ansari and Janhari, 1970).






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